Preheat your oven to 350°F (175°C). Gather your ingredients and prep your workspace.

In a skillet, heat about 2 tablespoons of olive oil over medium heat. Add chopped red onion and red bell pepper, sautéing for 5 minutes. Then, mix in minced garlic and cook for an additional minute.

In a large mixing bowl, combine approximately 1 pound of ground beef with Italian style breadcrumbs, grated Parmesan cheese, fresh parsley, eggs, tomato paste, salt, and pepper. Mix well with your hands.

On a sheet of parchment paper, transfer the meat mixture and shape it into an 8"x15" rectangle.

Layer slices of deli ham evenly over the meat rectangle, followed by fresh basil leaves and shredded mozzarella cheese, leaving a 1-inch border.

Carefully roll the meat mixture tightly from one end to the other, sealing the edges to contain all layers inside.

Place the rolled meatloaf in the preheated oven and bake for 1 hour. Tent with foil for the last 10 minutes.

Let the meatloaf rest for 10 minutes on the counter before slicing.

To serve, place a slice of Sicilian Meatloaf over a bed of cooked pasta or zucchini noodles, topped with marinara sauce.